Menu
Director's Message and Videos

Director's Message and Videos

Welcome to our web site. Thr...

Take a look

Take a look

Scientific and Technical Ser...

Personnel

Personnel

  Personnel List

Jobs

Jobs

Available Positions

Prev Next
Influence of the Relative Molecular Orientation on Interfacial Charge-Transfer Excitons at Donor/Acceptor Nanoscale Heterojunctions

Influence of the Relative Molecular Orientation on Interfacial Charge-Transfer Excitons at Donor/Acceptor Nanoscale Heterojunctions

Mahdieh Aghamohammadi, Anton Fernández, Malte Schmidt, Ana Pérez-Rodríguez, Alejandro Rodolfo Goñi, Jordi Fraxedas, Guillaume Sauthier, Markos Paradinas, Carmen Ocal, and Esther Barrena*. J. Phys. Chem. C, 2014, 118 (27), pp 14833–14839

Detection of the early stage of recombinational DNA repair by silicon nanowire transistors

  • Hits: 7998

nanolett26042012

Marco Chiesa, Paula P. Cardenas, Francisco Otón, Javier Martinez, Marta Mas-Torrent, Fernando Garcia, Juan C. Alonso, Concepció Rovira, Ricardo Garcia

Nano Lett. 2012, 12, 1275−1281.

dx.doi.org/10.1021/nl2037547

A silicon nanowire-based biosensor has been designed and applied for label-free and ultrasensitive detection of the early stage of recombinational DNA repair by RecA protein. Silicon nanowires transistors were fabricated by atomic force microscopy nanolithography and integrated into a microfluidic environment. The sensor operates by measuring the changes in the resistance of the nanowire as the biomolecular reactions proceed. We show that the nanoelectronic sensor can detect and differentiate several steps in the binding of RecA to a single-stranded DNA filament taking place on the nanowire-aqueous interface. We report relative changes in the resistance of 3.5% which are related to the interaction of 250 RecA·single-stranded DNA complexes. Spectroscopy data confirm the presence of the protein-DNA complexes on the functionalized silicon surfaces.







Organisation

Sc.&Technical Services

Scientific Highlights

Links of interest

pie2014

sts banner

logoeugris    mecgris    csicgris
bncbgris          uabgris        uabceigris      pruabgris