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Surfactant-free CO2-based microemulsion-like systems

Surfactant-free CO2-based microemulsion-like systems

                                                         Robert F. Hankel, Paula E. Rojas, Mary Cano-Sarabia, Santi Sala, Jaume Veciana, Andreas Braeuer* and Nora Ventosa* Chem. Commun., 2014,50, 8215-8218

Contact Lens Engineered with a Nanostructured Polymeric Sensing Film for Non-invasive Intraocular Pressure Monitoring

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09-11-2011-10-39-49

Figure 1. Left: doughnut shaped rigid CL used for fabricating the CLSs. Middle: modified CL showing the slightly coloured BL film glued on the CL equipped with wire connections. Right: measuring the IOP variations of a volunteer with the CLS.

Publications derived:

1) V. Laukhin et al., Sensors & Actuators: A, 170 (2011) 36-43

2) A. Moya et al., Int. J. E-Health and Medical Commun. 2, (2011) 1-19

3) I. Sanchez et al. Invest. Ophthalmol. Vis. Sci. Sept. 22 (2011). DOI, 10.1167/iovs.10-7064


In a CIBER-BBN joint project developed by researchers at the Institut de Ciència de Materials de Barcelona (ICMAB-CSIC), IOBA-Eye Institute, and Centro de Microelectrónica (CNM-CSIC), a new prototype of contact lens sensor (CLS) for monitoring, in a non-invasive way, intraocular pressure (IOP) variations has been developed. The CLS has as the key sensing element a new all-organic flexible highly piezo-resistive film sensor that is glued to the central hole of a doughnut-shaped contact lens (CL). The CLS were tested with an eye phantom and with enucleated pig-eyes by applying pressure changes between 7 to 32 mmHg, in increasing and decreasing pressure cycles induced by a low pressure transducer, recording the electrical changes in the sensor with a portable recorder. The developed CLS prototype, that is biocompatible, permits to transmit the changes in the cornea curvature, which are correlated with the IOP, directly to the flexible conducting polymeric sensor embedded in the CL. The electrical response of the CLS to pressure changes reveals a high linearity as well as a good reproducibility having the proper sensitivity to perform continuous IOP monitoring. A first test in a human volunteer has already been performed.

 

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