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IrOx–carbon nanotube hybrids: A nanostructured material for electrodes with increased charge capacity in neural systems

IrOx–carbon nanotube hybrids: A nanostructured material for electrodes with increased charge capacity in neural systems

Acta Biomaterialia, Volume 10, Issue 10, October 2014, Pages 4548–4558.     Nina M. Carretero, Mathieu P. Lichtenstein, Estela Pérez, Laura Cabana, Cristina Suñol, Nieves Casañ-Pastor

High Loading of Gentamicin in Bioadhesive PVM/MA Nanostructured Microparticles Using Compressed Carbon-Dioxide

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Elisa Elizondo, Santiago Sala, Edurne Imbuluzqueta, David González, María J. Blanco-Prieto, Carlos Gamazo, Nora Ventosa and Jaume Veciana

Pharmaceutical Research
Volume 28, Number 2, 309-321, DOI: 10.1007/s11095-010-0248-x

To investigate, for the first time, the viability of compressed antisolvent methodologies for the preparation of drug-loaded particles of the biodegradable and bioadhesive polymer poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA), utilizing gentamicin (Gm) as a model drug.

Precipitation with a Compressed Antisolvent (PCA) method was used for the preparation of PVM/MA particles loaded with gentamicin. Before encapsulation, gentamicin was modified into a hydrophobic complex, GmAOT, by exchanging its sulphate ions with an anionic surfactant. GmAOT:PVM/MA composites were fully characterized in terms of size, morphology, composition, drug distribution, phase composition, in vitro activity and drug release.

Homogeneous nanostructured microparticles of PVM/MA loaded with high and uniformly distributed quantities of GmAOT were obtained by PCA. The drug loading factors could be tuned at will, improving up to ten times the loadings obtained by other precipitation techniques. Gentamicin retained its bioactivity after being processed, and, according to its release profiles, after an initial burst it experienced a sustained release over 30 days.
Compressed antisolvent methods are suitable technologies for the one-step preparation of highly loaded nanostructured PVM/MA matrices with promising application in the delivery of low bioavailable drugs.
Electronic Supplementary Material The online version of this article (doi:10.1007/s11095-010-0248-x) contains supplementary material, which is available to authorized users.


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