Director's Message and Videos

Director's Message and Videos

Welcome to our web site. Thr...

Take a look

Take a look

Scientific and Technical Ser...



  Personnel List



Available Positions

Prev Next
Enhanced Thermal Oxidation Stability of Reduced Graphene Oxide by Nitrogen Doping

Enhanced Thermal Oxidation Stability of Reduced Graphene Oxide by Nitrogen Doping

Stefania Sandoval, Nitesh Kumar, Dr.  A. Sundaresan, Prof. C. N. R. Rao*, Prof. Amparo Fuertes and Dr. Gerard Tobias*. Chemistry - A European Journal, Volume 20, Issue 38, pages 11999–12003, September 15, 2014

Filled and glycosylated carbon nanotubes for in vivo radioemitter localization and imaging

  • Hits: 17668


S. Y. Hong, G. Tobias,*, K. T. Al-Jamal, B. Ballesteros, H. Ali-Boucetta, S. Lozano-Perez, P. D. Nellist, R. B. Sim, C. Finucane,
S. J. Mather, M. L. H. Green, K. Kostarelos* and B. G. Davis*, 

Nature Materials, 16 MAY 2010 | DOI: 10.1038/NMAT2766
Functionalization of nanomaterials for precise biomedical function is an emerging trend in nanotechnology. Carbon nanotubes are attractive as multifunctional carrier systems because payload can be encapsulated in internal space whilst outer surfaces can be chemically modified. Yet, despite potential as drug delivery systems and radiotracers, such filledand- functionalized carbon nanotubes have not been previously investigated in vivo. Here we report covalent functionalization of radionuclide-filled single-walled carbon nanotubes and their use as radioprobes. Metal halides, including Na125I,were sealed inside single-walled carbon nanotubes to create high-density radioemitting crystals9 and then surfaces of these filled–sealed nanotubes were covalently modified with biantennary carbohydrates, improving dispersibility and biocompatibility. Intravenous administration of Na125I-filled glyco-single-walled carbon nanotubes in mice was tracked in vivo using single-photon emission computed tomography. Specific tissue accumulation (here lung) coupled with high in vivo stability prevented leakage of radionuclide to high-affinity organs (thyroid/stomach) or excretion, and resulted in ultrasensitive imaging and delivery of unprecedented radiodose density. Nanoencapsulation of iodide within single-walled carbon nanotubes enabled its biodistribution to be completely redirected from tissue with innate affinity (thyroid) to lung. Surface functionalization of 125I-filled single-walled carbon nanotubes offers versatility towards modulation of biodistribution of these radioemitting crystals in a manner determined by the capsule that delivers them. We envisage that organ-specific therapeutics and diagnostics can be developed on the basis of the nanocapsule model described here.


Newsletter ICMAB



Sc.&Technical Services

Scientific Highlights

Links of interest


sts banner

logoeugris    mecgris    csicgris
bncbgris          uabgris        uabceigris      pruabgris