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Influence of the Relative Molecular Orientation on Interfacial Charge-Transfer Excitons at Donor/Acceptor Nanoscale Heterojunctions

Influence of the Relative Molecular Orientation on Interfacial Charge-Transfer Excitons at Donor/Acceptor Nanoscale Heterojunctions

Mahdieh Aghamohammadi, Anton Fernández, Malte Schmidt, Ana Pérez-Rodríguez, Alejandro Rodolfo Goñi, Jordi Fraxedas, Guillaume Sauthier, Markos Paradinas, Carmen Ocal, and Esther Barrena*. J. Phys. Chem. C, 2014, 118 (27), pp 14833–14839

Nobel Prize in Chemistry 2012

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The Nobel Prize in Chemistry for 2012 has been awarded to Robert Lefkowitz (left), Howard Hughes Medical Institute, Duke University, USA, and Brian Kobilka (right), Stanford University, USA, for their work on G-protein-coupled receptors (GPCRs).

 


GPCRs are members of the family of integral membrane proteins (IMPs), which mediate the transfer of material and signals between the environment and the cytoplasm. There are about 1,000 GPCRs in the human body, all of which have similar molecular structures, defined by an amino acid sequence which crosses the plasma membrane seven times. This similarity means GPCRs can be effectively targeted and today as many as 30–50 % of all prescription drugs are designed to "fit" these structures. This has led to new anti-histamines, ulcer drugs, and beta blockers that help relieve hypertension, angina, and coronary disease.

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