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NMR signal enhancement of >50 000 times in fast dissolution dynamic nuclear polarization

L. F. PintoI. Marín-MontesinosV. LloverasJ. L. Muñoz-GómezM. PonsJ. Veciana and J. Vidal-Gancedo*. Chem. Commun., 2017,53, 3757-3760. DOI: 10.1039/C7CC00635G

Herein, we report the synthesis and the study of a novel mixed biradical with BDPA and TEMPO radical units that are covalently bound by an ester group (BDPAesterTEMPO) as a polarizing agent for fast dissolution DNP. The biradical exhibits an extremely high DNP NMR enhancement of >50000 times, which constitutes one of the largest signal enhancements observed so far, to the best of our knowledge.

 

Related Topics: Biomaterials and materials for drug delivery, therapy, diagnostics and sensing

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