SOMMA
  • SCIENTIFIC HIGHLIGHTS

Novel Fe_sub3sub_O_sub4sub_@GNF@SiO_sub2sub_ nanocapsules fabricated through the combination of an _itin situit_ formation method and SiO_sub2sub_ coating process for magnetic resonance imaging

Changyong Lu,* Stefania Sandoval, Teresa Puig, Xavier Obradors, Gerard Tobias, Josep Rosa and Susagna Ricart. RSC Adv., 2017, 7, 24690. DOI: 10.1039/c7ra04080f

An in situ approach for the synthesis of Fe3O4 nanoparticles combined with a SiO2 coating process was employed to prepare Fe3O4@GNF@SiO>2 nanocapsules. Graphitised nanofibres (GNF) were initially filled with iron(III) acetylacetonate, and used as a precursor for the synthesis of ultrasmall Fe3O4 nanoparticles (4.6 nm in diameter) inside the cavities of GNF (Fe3O4@GNF) with a high density. By using a silica coating process, Fe3O4@GNF@SiO>2 nanocapsules were obtained. The presence of the silica shell not only prevented leakage of the nanoparticles from inside the GNF but also protected the magnetite nanoparticles from dissolution, even in harsh acidic conditions. Furthermore, the silica coating resulted in an increased dispersability of the nanocomposites in water. Magnetic resonance imaging (MRI) studies indicate relatively high Image ID:c7ra04080f-t1.gif relaxivities for Fe3O4@GNF nanocomposites and Fe3O4@GNF@SiO>2 nanocapsules revealing the potential application of these hybrid materials for bioimaging. Therefore, the coating of filled GNF with silica is as an excellent strategy for the protection of encapsulated payloads.

Tags: Biomaterials and materials for drug delivery, therapy, diagnostics and sensing

Also on ICMAB...

Search

Your experience on this site will be improved by allowing cookies Cookie Settings