The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo
Laura Cabana, Maxime Bourgognon, Julie T.-W. Wang, Andrea Protti, Rebecca Klippstein, Rafael T. M. de Rosales, Ajay M. Shah, Josep Fontcuberta, Ester Tobías-Rossell, Jane K. Sosabowski, Khuloud T. Al-Jamal, Gerard Tobias SMALL Volume 12, Issue 21 June 1, 2016 Pages 2893–2905DOI: 10.1002/smll.201502721.
Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent.
In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.