logo icmab ochoa 02 01 logo icmab ochoa 02 01
  • SCIENTIFIC HIGHLIGHTS

Two-Dimensional Microscale Engineering of Protein-Based Nanoparticles for Cell Guidance

Two-Dimensional Microscale Engineering of Protein-Based Nanoparticles for Cell Guidance

Scientific Highlights Biomaterials and materials for drug delivery, therapy, diagnostics and sensing 09 July 2013 5339 hits jags

1

W. I. Tatkiewicz, J. Seras-Franzoso, E. García-Fruitós, E. Vazquez, N. Ventosa, K. Peebo, I. Ratera,* A. Villaverde, J. Veciana*; 


ACSNano, 2013, 7, 4774–4784;

DOI: 10.1021/nn400907f

Cell responses, such as positioning, morphological changes, proliferation, and apoptosis, are the result of complex chemical, topographical, and biological stimuli. Here we show the macroscopic responses of cells when nanoscale profiles made with inclusion bodies (IBs) are used for the 2D engineering of biological interfaces at the microscale. A deep statistical data treatment of fibroblasts cultivated on supports patterned with green fluorescent protein and human basic fibroblast growth factor-derived IBs demonstrates that these cells preferentially adhere to the IB areas and align and elongate according to specific patterns. These findings prove the potential of surface patterning with functional IBs as protein-based nanomaterials for tissue engineering.

Related Topics: Biomaterials and materials for drug delivery, therapy, diagnostics and sensing

Also on ICMAB...

Search

Your experience on this site will be improved by allowing cookies Cookie Settings