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SCIENTIFIC HIGHLIGHTS

09 May 2014

highlysensitive

G. Sanchez, D. Curiel, W. Tatkiewcz, I. Ratera, A. Tarraga, J. Veciana, P. Molina

Chem. Sci., 2014, 5, 2328-2335

doi: 10.1039/c3sc53058b

A multidentate adsorbate having a bis(carbazolyl)urea unit, as a receptor for hydrogen pyrophosphate anions, and two cyclic bidentate alkyl disulfide groups, as linkers to gold surfaces, has been designed and synthesized. Self-assembled monolayers (SAMs) on gold of this adsorbate have been obtained and characterized showing a high robustness along with an extremely large sensitivity and selectivity for hydrogen pyrophosphate anions enabling to be used as a surface plasmon resonance (SPR) sensor for the detection of such anions at the ppt concentration level under physiological conditions.

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Bioactive materials for therapy and diagnosis

Highly sensitive and selective detection of the pyrophosphate anion biomarker under physiological conditions