N. Grimaldi, F. da Silva, N.V. Segovia, L. Ferrer-Tasies, S. Sala, J. Veciana,* and N. Ventosa*, Chem. Soc. Rev., 2016, 45, 6520—6545. DOI: 10.1039/C6CS00409A
This review presents the large plethora of lipid-based nanovescicles available nowadays, focusing on a new generation of non-liposomal L-NVs and showing their similarities and differences with respect to their ancestors (liposomes). Since the overspread of a nanomaterial to the market is also strongly dependent on the availability of technological-scale preparation methods, it also extensively review the current approaches exploited for L-NV production. The most cutting-edge approaches for their preparation based on compressed fluid (CF) technologies is highlighted since they show the potential to represent a game-change in the production of L-NVs, favoring their step from the bench to the market. Finally, this review briefly discusses L-NV applications in nanomedicine looking also for their future perspectives.