Bioactive materials for therapy and diagnosis

Computer simulations of the interaction between SARS-CoV-2 spike glycoprotein and different surfaces

Autores: David C. Malaspina and Jordi Faraudo
Citation: Biointerphases 15, 051008 (2020)
DOI: https://doi.org/10.1116/6.0000502
PlumX: Computer simulations of the interaction between SARS-CoV-2 spike glycoprotein and different surfaces
A prominent feature of coronaviruses is the presence of a large glycoprotein spike protruding from a lipidic membrane. This glycoprotein spike determines the interaction of coronaviruses with the environment and the host. In this paper, we perform all atomic molecular dynamics simulations of the interaction between the SARS-CoV-2 trimeric glycoprotein spike and surfaces of materials.

Biomaterials

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Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI

Autores: Songbai Zhang, Vega Lloveras, Daniel Pulido, Flonja Liko, Luiz F. Pinto, Fernando Albericio, Miriam Royo, and José Vidal-Gancedo*
Citation:
. 2020 Aug; 12(8): 772
Published online 2020 Aug 14
DOI: 10.3390/pharmaceutics12080772
PlumX: Radical Dendrimers Based on Biocompatible Oligoethylene Glycol Dendrimers as Contrast Agents for MRI
Finding alternatives to gadolinium (Gd)-based contrast agents (CA) with the same or even better paramagnetic properties is crucial to overcome their established toxicity. Herein we describe the synthesis and characterization of entirely organic metal-free paramagnetic macromolecules based on biocompatible oligoethylene glycol dendrimers fully functionalized with 5 and 20 organic radicals (OEG Gn-PROXYL (n = 0, 1) radical dendrimers) with the aim to be used as magnetic resonance imaging (MRI) contrast agents.
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Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer

Título : Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer
Autores: Dr. Marcos Couto, Catalina Alamón, Susana Nievas, Dr. Marina Perona, Dr. María Alejandra Dagrosa, Prof. Dr. Francesc Teixidor, Prof. Dr. Pablo Cabral, Prof. Dr. Clara Viñas, Prof. Dr. Hugo Cerecetto
Citation: Chem. Eur. J.
doi:10.1002/chem.202002963
PlumX: Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer
About 95 % of people diagnosed with glioblastoma die within five years. Glioblastoma is the most aggressive central nervous system tumour. It is necessary to make progress in the glioblastoma treatment so that advanced chemotherapy drugs or radiation therapy or, ideally, two‐in‐one hybrid systems should be implemented.

Biomaterials

  • Hits: 224

3D Reduced Graphene Oxide Scaffolds with a Combinatorial Fibrous-Porous Architecture for Neural Tissue Engineering

Autores: André F. Girão, Joana Sousa, Ana Domínguez-Bajo, Ankor González-Mayorga, Igor Bdikin, Eulalia Pujades-Otero, Nieves Casañ-Pastor, María Jesús Hortigüela, Gonzalo Otero-Irurueta, António Completo, María Concepción Serrano*, and Paula A.A.P. Marques*.
Citation: ACS Appl. Mater. Interfaces 2020, 12, 35, 38962–38975. Publication Date:August 5, 2020. 
https://doi.org/10.1021/acsami.0c10599
PlumX: 3D Reduced Graphene Oxide Scaffolds with a Combinatorial Fibrous-Porous Architecture for Neural Tissue Engineering

Graphene oxide (GO) assists a diverse set of promising routes to build bioactive neural microenvironments by easily interacting with other biomaterials to enhance their bulk features or, alternatively, self-assembling toward the construction of biocompatible systems with specific three-dimensional (3D) geometries.

Biomaterials

  • Hits: 403

Tris-pyridylmethylamine (TPMA) complexes functionalized with persistent nitronyl nitroxide organic radicals

Autores: Elena Badetti,* Vega Lloveras, Francesca Anna Scaramuzzo, Klaus Wurst, Jaume Veciana, José Vidal-Gancedo,* Giulia Licini and  Cristiano Zonta *
Citation: Dalton Trans., 2020,49, 10011-10016
https://doi.org/10.1039/D0DT01553A
PlumX: Tris-pyridylmethylamine (TPMA) complexes functionalized with persistent nitronyl nitroxide organic radicals

The chance to have persistent organic radicals in combination with metals has attracted much interest since it offers the possibility of having new functional molecules with multiple open-shell elements. In this study, we report the synthesis of two tripodal tris(2-pyridyl)methylamine ligands (TPMA) functionalized with nitronyl nitroxide persistent radicals. The newly formed ligands have been used to coordinate zinc(II), copper(II), iron(II) and cobalt(II).

Biomaterials

  • Hits: 469

Nomenclature for boranes and related species (IUPAC Recommendations 2019)

The most recent IUPAC recommendations concerning boron hydrides and related compounds appeared in 2005. These recommendations reinforced earlier IUPAC recommendations in the subject area that had been published in 1990, but was essentially a ‘holding’ chapter, leaving new recommendations for a subsequent edition.

Biomaterials

  • Hits: 341

Dye-Loaded Quatsomes Exhibiting FRET as Nanoprobes for Bioimaging

Fluorescent organic nanoparticles (FONs) are emerging as an attractive alternative to the well-established fluorescent inorganic nanoparticles or small organic dyes. Their proper design allows one to obtain biocompatible probes with superior brightness and high photostability, although usually affected by low colloidal stability.

Biomaterials

  • Hits: 501

Bicyclic α-Iminophosphonates as High Affinity Imidazoline I2 Receptor Ligands for Alzheimer’s Disease

Sònia Abás, Sergio Rodríguez-Arévalo, Andrea Bagán, Christian Griñán-Ferré, Foteini Vasilopoulou, Iria Brocos-Mosquera, Carolina Muguruza, Belén Pérez, Elies Molins, F. Javier Luque, Pilar Pérez-Lozano, Steven de Jonghe, Dirk Daelemans, Lieve Naesens, José Brea, M. Isabel Loza, Elena Hernández-Hernández, Jesús A. García-Sevilla, M. Julia García-Fuster, Milica Radan, Teodora Djikic, Katarina Nikolic, Mercè Pallàs, Luis F. Callado, Carmen Escolano*. J. Med. Chem. 2020. Publication Date:March 9, 2020

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Metallacarboranes on the Road to Anticancer Therapies: Cellular Uptake, DNA Interaction, and Biological Evaluation of Cobaltabisdicarbollide [COSAN]−

Fuentes, I. , García‐Mendiola, T. , Sato, S. , Pita, M. , Nakamura, H. , Lorenzo, E. , Teixidor, F. , Marques, F. and Viñas, C. (2018), Metallacarboranes on the Road to Anticancer Therapies: Cellular Uptake, DNA Interaction, and Biological Evaluation of Cobaltabisdicarbollide [COSAN]. Chem. Eur. J..

Cover, Biomaterials, 2018

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