Nanoparticles to modulate topography and ligand distribution at the nanoscale: impact on cell behavior

Marc Martínez Miguel, Nanomol-Bio, ICMAB-CSIC

Date: Thursday, 9 March 2023
Time: 11 AM
Venue: Institut de Ciència de Materials de Barcelona (ICMAB, CSIC) - Sala d'Actes Carles Miravitlles and ONLINE. Register here to attend by Zoom. 

Abstract:

Understanding the cell-material interactions is crucial for the development of tissue engineering strategies, aiming to treat disease and replace missing or damaged organs and tissues. In this thesis, a nanoarchitectonic approach has been explored, involving molecular self-assembly, to process two different organic nanoparticles – protein nanoparticles and quatsomes – on surfaces to biofunctionalize substrates for cell culture experiments. These nanoparticles provided a nanotopography that modulated ligand distribution at the nanoscale, enhancing cell adhesion and guidance. The results presented in this thesis highlight the importance of the properties at the nanoscale of the environment surrounding cells. The developed platforms will be useful in future cell culture studies, both for fundamental studies and for clinical applications.

Supervisors:

• Imma Ratera, Nanomol-Bio Group, ICMAB-CSIC
• Judith Guasch, Nanomol-Bio Group, ICMAB-CSIC
• Nora Ventosa, Nanomol-Bio Group, ICMAB-CSIC

PhD Comittee:

• President: Jesús Martínez de la Fuente, Instituto de Nanociencia y Materiales de Aragón (INMA-CSIC), Spain
• Secretary: Ana Paula Candiota Silveira, Universitat Autònoma de Barcelona (UAB), Spain
• Vocal: Anna Lagunas Targarona, Institut de Bioenginyeria de Catalunya (IBEC), Spain

University: Universitat Autònoma de Barcelona (UAB)
PhD Programme: Biochemistry, Molecular Biology and Biomedicine

Cells functionalized with organic nanoparticles under confocal microscopy.