The salts Na[ROC(O)Ph], Na[1-ROC(O)-1,12-C2B10H11], K2[1,4-(ROC(O))2-C6H4], and K2[1,12-(ROC(O))2-1,12-C2B10H10], where R is the cobaltabis(dicarbollide)-diethylene glycol group [3,3′-Co(8-(OCH2CH2OCH2CH2)-1,2-C2B9H10)(1′,2′-C2B9H11)]−, were synthesized from the corresponding carboxylate salt and the zwitterion [3,3′-Co(8-(CH2CH2O)2-1,2-C2B9H10)(1′,2′-C2B9H11)]. The dianion in K2[1,12-(ROC(O))2-1,12-C2B10H10] showed at least one K+ cation to be tightly bound to the dianion via K···O and K···H–B interactions with both p-carborane and cobaltabis(dicarbollide) clusters on the basis of NMR and MS data and support of hybrid-DFT computations.
An evaluation of the antimicrobial properties of these compounds revealed all of the salts to be highly effective antibacterial agents for four Gram-positive bacteria strains (standard minimum inhibitory concentration, MIC, of 1 mg/L for Na[ROC(O)Ph]; Na) and antifungal agents for three Candida albicans strains (MIC 4 mg/L for the salts K2 and K2). One of the four Gram-positive bacteria strains tested was a life-threatening superbug methicillin-resistant Staphylococcus aureus (MRSA) isolate, which is resistant to many commercial antimicrobial drugs.
The cobaltabis(dicarbollide) derivative Na has a remarkable inhibitory effect on the MRSA strain with an MIC of only 1 mg/L and a minimum bactericidal concentration (MBC) of 2 mg/L, thus suggesting its potential as an antibacterial agent against MRSA.
More information can be found in the Full Paper by Clara Viñas et al.:
Metallacarborane Assemblies as Effective Antimicrobial Agents, Including a Highly Potent Anti-MRSA Agent
Isabel Romero, Margarita Martinez-Medina, Carla Camprubí-Font, Ines Bennour, David Moreno, Luis Martínez-Martínez, Francesc Teixidor, Mark A. Fox, Clara Viñas
Organometallics 2020, 39, 23, 4253–4264. DOI: 10.1021/acs.organomet.0c00315