The Max Planck Partner Group “Dynamic Biomimetics for Cancer Immunotherapy” (Nanomol-Bio Group; ICMAB-CSIC) is looking for a PhD fellow to develop artificial extracellular matrices (ECM) based on 3D hydrogels to create patient-derived organoids as hematological cancer models.
The young researcher will join an international team and will work closely with Dr. Patricia Pérez Galán group at (IDIBAPS-Hospital Clinic de Barcelona) with the final objective of improving the current preclinical models to develop new cancer (immuno)therapies and decrease the use of laboratory animals, thus lessening the implied ethical and economic burden, as well as decreasing the translation problems associated to variations among species.
The PhD researcher will be incorporated in a highly multidisciplinary research line, and their responsibility will lie in the synthesis and physicochemical characterization of novel 3D hydrogels through spectroscopic techniques, rheology, SEM, X-ray tomography, etc. Moreover, the young researcher will actively participate in the formation and study of tumoroids of non-Hodgkin’s Lymphoma (NHL) at IDIBAPS-Hospital Clinic de Barcelona. In these experiments, the student will characterize the quality and suitability of the patient-derived tumoroids formed through biological techniques such as optical and fluorescence microscopy, ELISA, flow cytometry, among others; and will also use them to evaluate different (immuno)therapies, e.g. immune checkpoint inhibitors.
Led by Dr. Judith Guasch, this research group is established at the Institute of Materials Science of Barcelona (ICMAB-CSIC) in collaboration with the Max Planck Institute for Medical Research (Heidelberg, Germany), and is part of the Nanomol-Bio Group. The Partner Group is focused on the design, synthesis, and fabrication of bioinspired materials and the study of their interaction with cells for medical applications, especially those related to cancer immunotherapy.
Salary equivalent to a predoctoral fellowships from the Spanish Ministry; starting as soon as possible.
The recruitment process will be closed when a suitable candidate is found.
The Institute of Materials Science of Barcelona (ICMAB-CSIC) is a multidisciplinary research center focused on cutting-edge research in functional advanced materials in the fields of ENERGY, ELECTRONICS, NANOMEDICINE and application fields yet to imagine. The ICMAB is integrated within the Barcelona Nanocluster in Bellaterra (BNC-b), a research network that includes the UAB, the CSIC (ICMAB, IMB-CNM and ICN2) and IRTA, part of the UAB Research Park of the Universitat Autònoma de Barcelona (PRUAB) and the ALBA Synchrotron. The BNC-b aims to share advanced scientific equipment and promote and disseminate nanoscience and nanotechnology.
The ICMAB offers a complete range of scientific services, including a 10,000 class cleanroom (the Nanoquim Platform) that is open to interested parties, whether these are academic or from industry, and it participates in all kinds of educational and promotional activities. Many ICMAB researchers teach at the UAB Master's degree in Nanotechnology and Materials Science and also on the UAB degree on Nanoscience and Nanotechnology.