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PhD Theses

PhD Thesis Defense by Dolores Bueno on 20 March 2020 at 11 am

The PhD Researcher Dolores Bueno from the NANOMOL Group at ICMAB will defend her PhD thesis on Friday, 20 March 2020, at 11 am at the ICMAB. The PhD Thesis Defense will be by videoconference from the ICMAB Meeting Room. No public is allowed. 

Mar 24, 2020

Peptide functionalized nanoliposomes for biomolecule intracellular delivery, prepared using compressed CO2

by Dolores Bueno, NANOMOL Group, ICMAB-CSIC

Date: Friday, 20 March 2020
Time: 11 am
Venue: ICMAB - Sala de Juntes (Videoconference)

Abstract: Fabry disease is a rare disease caused by a gene mutation on the X-chromosome, which encodes α-galactosidase A (GLA) enzyme. The lack of GLA causes the accumulation of globotriaosylceramide at the lysosomes. The actual treatment is based in the enzyme replacement therapy (ERT), the intravenous administration of the enzyme. Nanotechnology is a powerful tool to develop enzyme-loaded nanosystems in order to ameliorate ERT efficacy.

DELOS-SUSP (Depressurization of an Expanded Organic Solution-Suspension) methodology enables the production of small unilamellar vesicles using compressed CO2. DELOS-SUSP allows the simultaneous encapsulation of different bioactives like RGD peptide and GLA in liposomes. This Thesis has used liposomes with RGD and GLA to generate a solid proof of concept for the treatment of Fabry disease.

Supervisor:

  • Nora Ventosa Rull, NANOMOL Group, ICMAB-CSIC
  • Elisabet González Mira, NANOMOL Group, ICMAB-CSIC

PhD Committee:

  • President: Salvador Borrós i Gómez, IQS
  • Secretary: Inmaculada Ratera Bastardas, ICMAB-CSIC
  • Vocal:  Marisa García López, UB

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