Study of new liposomes for the delivery of enzymes through biological membranes

by Judit Tomsen, NANOMOL group (ICMAB-CSIC)

Date: Thursday, 15 July 2021
Time: 11 am
Venue: ICMAB Seminar Room "Carles Miravitlles" and online session by Zoom. Register here to attend by Zoom. 

Abstract: Liposomes are lipid-based nanovesicles widely explored as nanocarriers for the transport of biomolecules or drugs of interest to the place of action, and for the development of new nanomedicines. This Thesis is devoted to the study of liposomal systems functionalized with targeting-ligands, with the final goal to be used as nanocarriers of therapeutically active enzymes. The new liposomal formulations have been specifically investigated and developed for the effective transportation of α-galactosidase A enzyme through cellular and blood-brain membranes, and for the achievement of a new liposomal intravenous pharmaceutical product candidate (nanoGLA) for the treatment of Fabry disease. The achieved results support the strong potential of targeted liposomal systems for drug delivery application. The successful development and optimization of the nanoGLA product for improving the current enzymatic replacement therapy in Fabry disease especially contributes as an example of translational and interdisciplinary research.

Supervisors: 

• Nora Ventosa, NANOMOL group, ICMAB-CSIC
• Elisabet González, NANOMOL group, ICMAB-CSIC

PhD Committee:

• President: Silvia Muro, Institute for Bioengineering of Catalonia (IBEC), Spain
• Secretary: Marina Giannotti, Institute for Bioengineering of Catalonia (IBEC), Spain
• Vocal: Jordi Díaz Manera, Newcastle University, UK

University: Universitat Autònoma de Barcelona (UAB)
PhD Programme: Materials Science Doctoral Program