The PhD researcher Roberto Fabião Santos Abreu, from the Nanomol-Bio Group at ICMAB-CSIC, will defend his PhD thesis on Thursday, 21 April 2022 at 10 am at ICMAB.
by Roberto Fabião Santos Abreu, from the Nanomol-Bio Group at ICMAB-CSIC
Date: Thursday, 21 April 2022
Time: 10:00 am
Venue: ICMAB - Sala d'Actes Carles Miravitlles and online. Register here to attend by Zoom.
Abstract: Recent achievements in the field of immunotherapy, such as the development of engineered T cells used in adoptive cell therapy, are introducing more efficient strategies to combat cancer. Nevertheless, these T cells are challenging to manufacture, manipulate, and control. Specifically, there are limitations in producing the large amounts of specific T cells needed for these therapies in a short period of time and in an economically viable manner.
During my studies, we have studied different 3D systems with the objective of achieving higher proliferation rates and tune the resulting phenotypes, by resembling the natural environment of the secondary lymphoid organs.
University: Universitat Autònoma de Barcelona
PhD Programme: Materials Science Programme
Simplified scheme of a representative hydrogel as a biomimetic material for cancer immunotherapies. Normalized replication index values from the best conditions found on each 3D hydrogel (with Dynabeads) used on this doctoral Thesis for culturing and expanding primary human CD4+ T cells.