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SCIENTIFIC HIGHLIGHTS

Facile, fast and green synthesis of a highly porous calcium-syringate bioMOF with intriguing triple bioactivity
26 May 2023

A facile, fast and green strategy based on ethanol is utilized to prepare a new bioMOF, namely, CaSyr-1, with particular characteristics of full biocompatibility given by using just calcium and syringic acid, the latter being a phenolic natural product found in fruits and vegetables, permanent porosity with an outstanding surface area >1000 m2 g−1, and a micropore diameter of 1.4 nm close to mesopore values. Collectively, these data establish CaSyr-1 as one of the most porous bioMOFs reported to date, with high molecular adsorption capacity.

The CaSyr-1 adsorptive behavior is revised here through the reversible adsorption of CO2 and the encapsulation of bioactive ingredients in the structure. Remarkably, CaSyr-1 enables the development of triple therapeutic entities, involving bioactive Ca2+, syringic acid and an impregnated drug.

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M4HTH Smart Nanomedicine

Facile, fast and green synthesis of a highly porous calcium-syringate bioMOF with intriguing triple bioactivity


Albert Rosado, * Oriol Vallcorba, Blanca Vázquez-Lasa, Luís García-Fernández, Rosa Ana Ramírez-Jiménez, María Rosa Aguilar, Ana M. López-Periago, Concepción Domingo * and José A. Ayllón

Inorg. Chem. Front., 2023,10, 2165-2173
DOI:https://doi.org/10.1039/D2QI02639B