Metalla‐bis‐dicarbollides, such as the cobalta‐bis‐dicarbollide (COSAN) anion [Co(C2B9H11)2]−, have attracted much attention in biology but a deep understanding of their interactions with cell components is still missing. For this purpose, we studied the interactions of COSAN with the glucose moiety, which is ubiquitous at biological interfaces.
Octyl‐glucopyranoside surfactant (C8G1) was chosen as a model as it self‐assembles in water and creates a hydrated glucose‐covered interface. At low COSAN content and below the critical micellar concentration (CMC) of C8G1, COSAN binds to C8G1 monomers through the hydrophobic effect. Above the CMC of C8G1, COSAN adsorbs onto C8G1 micelles through the superchaotropic effect. At high COSAN concentrations, COSAN disrupts C8G1 micelles and the assemblies become similar to COSAN micelles but with a small amount of solubilized C8G1. Therefore, COSAN binds in a versatile way to C8G1 through either the hydrophobic or superchaotropic effect depending on their relative concentrations.
Hits: 281
Bioactive materials for therapy and diagnosis
Highlights on the Binding of Cobalta‐Bis‐(Dicarbollide) with Glucose Units
Tania Merhi, Alban Jonchère, Dr. Luc Girard, Dr. Olivier Diat, Miquel Nuez, Prof. Clara Viñas, Dr. Pierre Bauduin
Chem. Eur. J. 2020, 26, 13935
DOI: https://doi.org/10.1002/chem.202002123
Also at ICMAB
-
Nanostructure ITO and Get More of It. Better Performance at Lower Cost
- Information
- 26 February 2021 176 hit(s) Biomaterials
In this paper, we investigated how different growth conditions (i.e., temperature, growth time, and composition) allows for trading off cost (i.e., In content) and performance of nanostructured indium tin oxide (ITO) for biosensing applications. Next, we compared the behavior of these functionalized nanostructured surfaces obtained in different growth conditions between each other and with a standard thin film as a reference, observing improvements in effective detection area up to two orders of magnitude. This enhanced the biosensor’s sensitivity, with higher detection level, better accuracy and higher reproducibility. -
Sunitinib-Containing Carborane Pharmacophore with the Ability to Inhibit Tyrosine Kinases Receptors FLT3, KIT and PDGFR-β, Exhibits Powerful In Vivo Anti-Glioblastoma Activity
- Information
- 19 February 2021 193 hit(s) Biomaterials
Malignant gliomas are the most common malignant and aggressive primary brain tumors in adults, the prognosis being—especially for glioblastomas—extremely poor. There are no effective treatments yet. However, tyrosine kinase receptor (TKR) inhibitors and boron neutron capture therapy (BNCT), together, have been proposed as future therapeutic strategies. In this sense in our ongoing project of developing new anti-glioblastoma drugs, we identified a sunitinib-carborane hybrid agent, 1, with both in vitro selective cytotoxicity and excellent BNCT-behavior. -
Nanorods Based on Mesoporous Silica Containing Iron Oxide Nanoparticles as Catalytic Nanomotors: Study of Motion Dynamics
- Information
- 12 February 2021 197 hit(s) Biomaterials
Self‐propelled particles and, in particular, those based on mesoporous silica, have raised considerable interest due to their potential applications in the environmental and biomedical fields thanks to their biocompatibility, tunable surface chemistry and large porosity. Although spherical particles have been widely used to fabricate nano‐ and micromotors, not much attention has been paid to other geometries, such as nanorods. -
Computer simulations of the interaction between SARS-CoV-2 spike glycoprotein and different surfaces
- Information
- 15 January 2021 319 hit(s) Biomaterials
A prominent feature of coronaviruses is the presence of a large glycoprotein spike protruding from a lipidic membrane. This glycoprotein spike determines the interaction of coronaviruses with the environment and the host. In this paper, we perform all atomic molecular dynamics simulations of the interaction between the SARS-CoV-2 trimeric glycoprotein spike and surfaces of materials. -
Bimodal Therapeutic Agents Against Glioblastoma, One of the Most Lethal Forms of Cancer
- Information
- 22 December 2020 336 hit(s) Biomaterials
About 95 % of people diagnosed with glioblastoma die within five years. Glioblastoma is the most aggressive central nervous system tumour. It is necessary to make progress in the glioblastoma treatment so that advanced chemotherapy drugs or radiation therapy or, ideally, two‐in‐one hybrid systems should be implemented.
